AnswerBy Multiday Running Editorial TeamUpdated June 11, 2026

How to Prevent Blisters in an Ultramarathon

Blister prevention in ultramarathons requires a multi-layer approach: pre-tape known hot spots with Leukotape before the race, change socks every 4–6 hours, rotate between 2–3 pairs of shoes as feet swell (expect 1–2 size increase), and apply lubricant (Body Glide or Squirrel's Nut Butter) at every shoe change. The most important single factor is sock choice — moisture-wicking wool or synthetic, never cotton.

Reviewed against our editorial policy. This is educational content, not medical advice.

The Short Answer

Blisters affect 80%+ of multiday runners, but they don't have to end your race. The difference between a DNF and a finish is often just proactive foot care — addressing problems before they become crises. See our best shoes for 24-hour races guide for footwear recommendations.

The Prevention Protocol

ActionWhenWhy
Pre-tape hot spotsBefore race startLeukotape on heels, balls, toes reduces friction
Change socksEvery 4–6 hoursRemoves moisture, resets skin environment
Rotate shoesEvery 6–12 hoursAccommodates swelling, changes pressure points
Apply lubricantEvery shoe changeBody Glide or equivalent between toes, on heels
Immediate treatmentAt first hot spotDrain, tape, and monitor — never ignore

Shoe Sizing for Ultras

Your feet will swell 1–2 full sizes during a 24-hour+ event. Bring shoes in your normal race size plus 0.5 and 1.0 sizes up. Start in your normal size and switch to larger shoes when tightness begins — typically around hours 6–10.

Treat Hot Spots Immediately

The most important blister rule is to stop early. A hot spot is not a minor annoyance in a multiday event; it is the warning phase before skin separation. If you feel heat, rubbing, or a small sharp point of pressure, stop at the next aid station and fix it before the skin lifts.

Dry the area, smooth the skin, apply tape without wrinkles, and change the pressure point if possible by loosening laces or switching shoes. If a blister has already formed, drain only if you know how to keep the roof intact and cover it cleanly. Dirty blister care can create a much bigger problem than the blister itself.

Crew and Drop-Bag Setup

Pack foot care so it is visible and usable when you are tired: tape, small scissors, alcohol wipes, lubricant, spare socks, and a towel in the same bag. Put one duplicate kit in a drop bag or crew box. The fastest blister kit is the one you can find without searching.

Sources

  1. Hoffman, M.D. (2016) — "Foot problems in ultramarathon runners." Wilderness & Environmental Medicine, 27(4), 470–478.
  2. Krabak, B.J. et al. (2011) — "Foot injuries in ultramarathons." Current Sports Medicine Reports, 10(5), 295–303.

Frequently Asked Questions

How do you prevent blisters during an ultramarathon?

Pre-tape hot spots, change socks every 4–6 hours, rotate shoes, apply lubricant at every change, and never use cotton socks. Address hot spots immediately — a blister that could have been a tape job at hour 6 becomes a medical issue at hour 20.

What socks are best for ultramarathons?

Moisture-wicking wool (Injinji, Darn Tough) or synthetic blends. Toe socks (Injinji) reduce inter-toe friction. Never cotton — it retains moisture and accelerates blister formation.

Go Deeper

Explore our comprehensive guides, training plans, and gear reviews for multiday running.