AnswerUpdated May 12, 2026

How to Prevent Blisters in an Ultramarathon

Blister prevention in ultramarathons requires a multi-layer approach: pre-tape known hot spots with Leukotape before the race, change socks every 4–6 hours, rotate between 2–3 pairs of shoes as feet swell (expect 1–2 size increase), and apply lubricant (Body Glide or Squirrel's Nut Butter) at every shoe change. The most important single factor is sock choice — moisture-wicking wool or synthetic, never cotton.

The Short Answer

Blisters affect 80%+ of multiday runners, but they don't have to end your race. The difference between a DNF and a finish is often just proactive foot care — addressing problems before they become crises. See our best shoes for 24-hour races guide for footwear recommendations.

The Prevention Protocol

ActionWhenWhy
Pre-tape hot spotsBefore race startLeukotape on heels, balls, toes reduces friction
Change socksEvery 4–6 hoursRemoves moisture, resets skin environment
Rotate shoesEvery 6–12 hoursAccommodates swelling, changes pressure points
Apply lubricantEvery shoe changeBody Glide or equivalent between toes, on heels
Immediate treatmentAt first hot spotDrain, tape, and monitor — never ignore

Shoe Sizing for Ultras

Your feet will swell 1–2 full sizes during a 24-hour+ event. Bring shoes in your normal race size plus 0.5 and 1.0 sizes up. Start in your normal size and switch to larger shoes when tightness begins — typically around hours 6–10.

Sources

  1. Hoffman, M.D. (2016) — "Foot problems in ultramarathon runners." Wilderness & Environmental Medicine, 27(4), 470–478.
  2. Krabak, B.J. et al. (2011) — "Foot injuries in ultramarathons." Current Sports Medicine Reports, 10(5), 295–303.

Go Deeper

Explore our comprehensive guides, training plans, and gear reviews for multiday running.